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Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000007011
Taxonomy439855 - Escherichia coli (strain SMS-3-5 / SECEC)
StrainSMS-3-5 / SECEC
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000019645.1 from ENA/EMBL
Pan proteomei This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)

Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

E.coli strain SECEC SMS-3-5 was isolated from Shipyard Creek, USA, an industrial, toxic metal-contaminated coastal environment. It is resistant to a record-number of antibiotics, in many cases at record-high concentrations. This is the first case of resistance to ciprofloxacin and moxifloxacin, two front-line fluoroquinolones, in an environmental strain. By multilocus sequence typing it belongs to a clade close to the last common E.coli/Shigella ancestor. It belongs to phylogenetic group D and is serptype O19:H34 (modified from PubMed 18708504 ).


Component nameGenome Accession(s)
Plasmid pSMS35_130141
Plasmid pSMS35_810
Plasmid pSMS35_44
Plasmid pSMS35_33


  1. "Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5."
    Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C., Ravel J., Stepanauskas R.
    J. Bacteriol. 2008:6779-6794(2008) [PubMed] [Europe PMC] [Abstract]
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