Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Overview

Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 1,223
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000006901
Taxonomy445985 - Borrelia burgdorferi (strain ZS7)
StrainZS7
Last modifiedJuly 25, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000021405.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) pan proteome (fasta)

Borreliae, the causative agent of Lyme disease, are obligatorily bound to their host organisms for survival. It is a Spirochetes, a spiral-shaped bacterium. Highly specialized, motile, with two membranes, it lives primarily as an extracellular pathogen. During their life cycle they switch from the invertebrate host tick (Ixodes spec.) to various vertebrate hosts via a tick bite. It seems that Borellia have three indispensable components; a chromosome, a circular plasmid of approximately 26 kb (maybe ZS7_cp26 in B.burgdorferi) and a linear plasmid of approximately 54 kb (probably ZS7_lp54 in B.burgdorferi ZS7), each species can also contain many other plasmids. The range of vertebrates and invertebrates used as hosts is thought to be mediated by factors encoded mainly on a large number of different plasmids found in Borreliae genomes. These plasmids are characterized by their wealth of paralogous genes. It is thought that Borreliae plasmids are not stable and are frequently rearranged leading to differing plasmid content within a species. The chromosome is also involved in fission/fusion events, and the right end of the chromosome of B. burgdorferi strains is variable due to its ability to catch plasmids. During passage plasmids can be lost due to the lack of selection pressure, which can be accompanied by the inability of Borreliae to prosper in the host. Strain ZS7 was isolated from Ixodes rizinus ticks collected by flagging in the Freiburg, Germany area in the 1980s.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome808
Plasmid ZS7_lp2517
Plasmid ZS7_lp5455
Plasmid ZS7_cp32-1239
Plasmid ZS7_lp3623
Plasmid ZS7_cp32-3+1060
Plasmid ZS7_lp28-322
Plasmid ZS7_lp1714
Plasmid ZS7_cp32-136
Plasmid ZS7_lp28-421
Plasmid ZS7_cp32-440
Plasmid ZS7_lp28-231
Plasmid ZS7_lp28-113
Plasmid ZS7_cp32-935
Plasmid ZS7_cp2625

Publications

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again