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Overview

StatusReference proteome
Proteinsi3,826
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000006469
Taxonomy523841 - Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)
StrainATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4
Last modifiedNovember 9, 2018
Genome assembly and annotationi GCA_000306765.2 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) (Halobacterium mediterranei) pan proteome (fasta)

Polyhydroxyalkanoates (PHAs) are biodegradable polyesters present in most genera of bacteria and in Halobacteriaceae members of archaea. PHAs usually accumulate when cells are cultivated in an environment with an excess of carbon sources and limited nitrogen, phosphorus, or oxygen. Serving as carbon and energy storage compounds, PHAs are often found in the cytoplasm as insoluble inclusions that are also known as PHA granules. Many proteins coated onto PHA granules (PHA granule-associated proteins (PGAPs)) have been shown to be responsible for PHA synthesis and granule formation. The major proteins present on PHA granules, the phasins (PhaPs), constitute approximately 5% (wt/wt) of total cellular proteins. In addition to their main roles in preventing PHA granules from aggregating and in preventing the nonspecific attachment of other proteins to PHA granules, phasins are proposed to be involved in the regulation of PHA synthesis, PHA degradation, PHA granule size control, the formation of networks on the PHA granule surface, and even the distribution of PHA granules during cell division, a dramatic role displayed by phasin PhaF and the phasin-like PhaM. Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4) is an extremely halophilic, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) producer archaeon isolated from seawater evaporation ponds near Alicante, Spain. It exhibits remarkable metabolic efficiency and genome stability at high salt concentrations and thus has served as a good model for haloarchaeal physiology and metabolism studies for several decades. H. mediterranei is capable of accumulating poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) from many cheap carbon sources. It possesses 2 key enzymes (PhaEC and PhaB) and a structure protein (PhaP) involved in PHBV biosynthesis. (Adapted from PMID: 22843593 & 22247127).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome2940
Plasmid pHM100129
Plasmid pHM300287
Plasmid pHM500470

Publications

  1. "Complete genome sequence of the metabolically versatile halophilic archaeon Haloferax mediterranei, a poly(3-hydroxybutyrate-co-3-hydroxyvalerate) producer."
    Han J., Zhang F., Hou J., Liu X., Li M., Liu H., Cai L., Zhang B., Chen Y., Zhou J., Hu S., Xiang H.
    J. Bacteriol. 2012:4463-4464(2012) [PubMed] [Europe PMC] [Abstract]
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