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Overview

Proteinsi2,583
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000006386
Taxonomy426430 - Staphylococcus aureus (strain Newman)
StrainNewman
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000010465.1 from ENA/EMBL
Pan proteomei This proteome is part of the Staphylococcus aureus (strain NCTC 8325) pan proteome (fasta)

Gram-positive nonmotile coccus that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. Staphylococcus aureus is one of the major causes of community- acquired and hospital-acquired infections. It produces numerous toxins including superantigens that cause unique disease entities such as toxic-shock syndrome and staphylococcal scarlet fever.

Staphylococcus aureus (strain Newman) was isolated in 1952 from a human infection and has been used extensively in animal models of staphylococcal disease due to its robust virulence phenotype. It possesses four integrated prophages and two large pathogenicity islands. The two major pathogenicity islands vSa alpha and vSa beta are present as well as vSa gamma and vSa4. The vSa4 of the strain Newman, unlike the one in strain N315, lacks virulent determinants and codes for one integrase and three proteins of unknown function. Many virulence genes are encoded by prophages and it is likely that the virulence of the strain Newman largely rely on them. Staphylococcus aureus (strain Newman) has few insertion sequences and lacks known antibiotic-resistance determinants. The fibronectin-binding proteins, FnbA and FnbB are present but lack the C-terminal cell wall sorting signal.

Componentsi

Component nameGenome Accession(s)
Proteins
Chromosome2583

Publications

  1. "Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands."
    Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.
    J. Bacteriol. 2008:300-310(2008) [PubMed] [Europe PMC] [Abstract]
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