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StatusReference proteome
Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome%5Fredundancy">more...</a>)</p> 3,062
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="">proteome</a>. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000006135
Taxonomy990288 - Acidithiobacillus caldus (strain SM-1)
Last modifiedMarch 22, 2020
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="">more...</a>)</p> GCA_000221025.1 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Acidithiobacillus caldus (strain SM-1) pan proteome (fasta)
CompletenessClose to Standard

Acidithiobacillus caldus (strain SM-1) is a moderately thermoacidophilic, obligately chemolithotrophic, Gram-negative bacterium isolated from a pilot bioleaching reactor. It is the dominant sulfur-oxidizing bacterium in biomining and it is also found to be associated with acid mine drainage. The main roles of A. caldus in biomining processes include: 1) to oxidize elemental sulfur and reduced inorganic sulfur compounds (RISCs), thus produces the acidity that is essential for biomining and 2) to remove the accumulated elemental sulfur that would otherwise retard the oxidation of ores. It is shown that RISC oxidation in A. caldus is coupled to ATP generation via electron transport phosphorylation. A.caldus is also one of the dominant sulfur-oxidizing bacteria in bioleaching reactors. It plays the essential role in maintaining the high acidity and oxidation of reduced inorganic sulfur compounds during bioleaching process. A. caldus encodes all enzymes for the central metabolism and the assimilation of carbon compounds, among which 29 proteins/enzymes are identifiable with proteomic tools. A.caldus fixes CO2 via the classical Calvine-Basshame-Benson (CBB) cycle, and can operate complete Embden-Meyerhof pathway (EMP), pentose phosphate pathway (PPP), and gluconeogenesis. It has an incomplete tricarboxylic acid cycle (TCA). It has an optimal growth temperature around 40-45 degrees Celsius and pH of 2-2.5. (Adapted from PMID: 21703548).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
Plasmid megaplasmid241
Plasmid pLAtc110
Plasmid pLAtc213
Plasmid pLAtc328


  1. "Unraveling the Acidithiobacillus caldus complete genome and its central metabolisms for carbon assimilation."
    You X.Y., Guo X., Zheng H.J., Zhang M.J., Liu L.J., Zhu Y.Q., Zhu B., Wang S.Y., Zhao G.P., Poetsch A., Jiang C.Y., Liu S.J.
    J. Genet. Genomics 38:243-252(2011) [PubMed] [Europe PMC] [Abstract]
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