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StatusReference proteome
Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 1,976
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000002727
Taxonomy523850 - Thermococcus onnurineus (strain NA1)
Last modifiedSeptember 23, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="">more...</a>)</p> GCA_000018365.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Thermococcus onnurineus (strain NA1) pan proteome (fasta)

Thermococcus onnurineus (strain NA1) is a sulfur-reducing hyperthermophilic carboxydotrophic archaeum isolated from a deep-sea hydrothermal vent sediment (at a depth of 1650 meters) in the PACMANUS field of the East Manus Basin. T. onnurineus requires elemental sulfur as a terminal electron acceptor for heterotrophic growth on peptides or an amino acid mixture and exhibits optimum growth at 80 degrees Celsius and pH 8.5. It has a single circular chromosome, which possesses a unique gene cluster CODH (Carbon monoxide dehydrogenase). This genome encodes unique proteins involved in carboxydotrophy to generate energy by oxidation of CO to CO2 (carboxydotrophy), thereby providing a mechanistic basis for growth with CO as a substrate. This lithotrophic feature in combination with carbon fixation via RuBisCO (ribulose 1,5-bisphosphate carboxylase/oxygenase) introduces a new strategy with a complementing energy supply for T. onnurineus potentially allowing it to cope with nutrient stress in the surrounding of hydrothermal vents, providing the first genomic evidence for the carboxydotrophy in Thermococcus. The novel combination of carbon fixation and carboxydotrophy suggests that when heterotrophic substrates are not available and CO2 formed by catabolism is limited, the CO2 yield from CO oxidation would be a suitable substrate for the RuBisCO enzyme.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)


  1. "The complete genome sequence of Thermococcus onnurineus NA1 reveals a mixed heterotrophic and carboxydotrophic metabolism."
    Lee H.S., Kang S.G., Bae S.S., Lim J.K., Cho Y., Kim Y.J., Jeon J.H., Cha S.-S., Kwon K.K., Kim H.-T., Park C.-J., Lee H.-W., Kim S.I., Chun J., Colwell R.R., Kim S.-J., Lee J.-H.
    J. Bacteriol. 2008:7491-7499(2008) [PubMed] [Europe PMC] [Abstract]
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