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Overview

Proteinsi1,974 sequences in UniParc
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000002569
Taxonomy668336 - Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1)
StrainD11S-1
Last modifiedOctober 22, 2018
Genome assembly and annotationi GCA_000146265.4 from ENA/EMBL

Aggregatibacter actinomycetemcomitans serotype C (strain D11S-1) is a Gram-negative bacterium isolated from a subject with aggressive periodontitis. It typically resides in the oral cavity of humans and animals and can cause a number of diseases. A. actinomycetemcomitans is a major etiologic agent of human periodontal disease, in particular aggressive periodontitis, which results in devastation to the bone supporting the teeth. Adherence to oral surfaces is controlled through the tad (tight adherence) locus, which may express proteins that are involved in type IV secretion. The bacterium actively suppresses immune responses through a number of secreted proteins, two of which are toxins; leukotoxin and cytolethal distending toxin. This organism causes bone destruction by interfering with the osteoblast/osteoclast (bone-forming cell/bone resorption cell) control mechanisms that normally ensure constant bone remodeling through a number of expressed proteins. A. actinomycetemcomitans can also invade nonphagocytic cells and spread intercellularly, causing apoptotic destruction of host epithelial layers. (Adapted from www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&cmd=ShowDetailView&TermToSearch=40107 and PMID: 19820097).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
UniParc sequence(s)
Chromosome1889
Plasmid S2543
Plasmid S5742

Publications

  1. "Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1."
    Chen C., Kittichotirat W., Si Y., Bumgarner R.
    J. Bacteriol. 2009:7378-7379(2009) [PubMed] [Europe PMC] [Abstract]
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