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Overview

Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 917
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000002532
Taxonomy315277 - Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)
StrainATCC VR-571B / DSM 19440 / HAR-13
Last modifiedJuly 25, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000012125.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Chlamydia trachomatis (strain D/UW-3/Cx) pan proteome (fasta)

Chlamydia trachomatis infection is an important cause of preventable blindness and sexually transmitted disease (STD) in humans. There are 15 serovariants that exhibit distinct organotropism for the eye or the urogenital tract and are separated according to the pathobiotypes. Trachoma biovariants consist of serovars A, B, Ba, C, D, E, F, G, H, I, J and K. LGV (Lymphogranuloma venereum) biovariants consist of serovars L1, L2 and L3. Trachoma biovariants are noninvasive and epitheliotropic strains that cause blinding trachoma (A to C) or sexually transmitted diseases. LGV biovariants cause sexually transmitted diseases with disseminating infection of draining regional lymph nodes. The trpBA operon encoding tryptophan synthase is functional in STD serovars, whereas trpBA harbors mutations that inactivate the enzyme in ocular serovars. Chlamydia trachomatis is an obligate intracellular parasite depending on the host machinery for ATP synthesis. Chlamydial life cycle comprehends an intracellular metabolically- active "reticular body" and an inert extracellular spore-like "elementary body" equipped with a unique disulfide-cross-linked protein envelope.

Chlamydia trachomatis (strain A/HAR-13 / ATCC VR-571B) is an oculotropic strain derived from a clonal population originating from a single plaque-purified isolate. It harbors a chromosome and a plasmid. Even though the genomes of strains D/UW-3 and A/HAR-13 / ATCC VR-571B are 99.6% identical, they possess a number of important differences that may be involved in disease organotropism determination. A large in-frame deletion was found in the gene coding for Tarp. A 125bp deletion was found and was shown to be unique to oculotropic serovars. There are 8 interrupted ORFs in strain A/HAR-13 / ATCC VR-571B compared to strain D/UW-3. Whereas the strain D/UW-3 possesses 2 copies of tyrP, the second copy is disrupted in strain A/HAR-13 / ATCC VR-571B. A total of 3354 SNPs were identified between strain A/HAR-13 / ATCC VR-571B and strain D/UW-3. Nine SNPs are localized within RNA encoding regions, 226 in intergenic regions and 3119 in coding regions.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome909
Plasmid pCTA8

Publications

  1. "Comparative genomic analysis of Chlamydia trachomatis oculotropic and genitotropic strains."
    Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.
    Infect. Immun. 2005:6407-6418(2005) [PubMed] [Europe PMC] [Abstract]
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