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Overview

Proteinsi5,270
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000002519
Taxonomy83334 - Escherichia coli O157:H7
StrainO157:H7 / EDL933 / ATCC 700927 / EHEC
Last modifiedMarch 29, 2019
Genome assembly and annotationi GCA_000006665.1 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)

Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

E.coli O157:H7, phylogroup E, is a enterohemorrhagic strain producing large quantities of one or more related, potent toxins that cause severe damage to the lining of intestine. These toxins are closely related to the toxin produced by Shigella dysenteriae. The acute disease caused by the bacterium is called hemorrhagic colitis and is characterized by severe cramping and diarrhea. Undercooked or raw hamburger has been implicated in nearly all documented outbreaks and in other sporadic cases. Raw milk was the vehicle in a school outbreak in Canada.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome5169
Plasmid pO157102
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Main funding by: National Institutes of Health

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