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Overview

StatusReference proteome
Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome%5Fredundancy">more...</a>)</p> 5,200
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a>. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000002428
Taxonomy284593 - Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
StrainATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65
Last modifiedJanuary 15, 2020
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000002545.2 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) pan proteome (fasta)
BuscoC:98.3%[S:97.8%,D:0.5%],F:1.5%,M:0.2%,n:1711
CompletenessStandard

Candida glabrata, previously classified as Torulopsis glabrata, is a yeast that forms part of the normal microbial flora of the mouth gastrointestinal tract, skin, vagina, and stool and can affect people of any age. It is found in the environment, particularly on leaves, flowers, water, and soil. Candida glabrata colonies are small, pasty, white to cream in colour and glistening. Candida glabrata has emerged as one of the most common causes of candidiasis (candidosis). Candidiasis can range from superficial disorders such as nappy rash to invasive, rapidly fatal infections in immunocompromised hosts. Candida albicans is most commonly responsible for candidiasis, however C. glabrata currently ranks second or third as the causative agent of superficial (oral, esophageal, vaginal, or urinary) or systemic candidal infections worldwide. Males and females are affected equally by most forms of Candida species. In women, candidal infection is the second most common cause of vaginitis and in either sex, chronic yeast infections, caused by Candida species, are common first symptoms of HIV infection. In adults, oral candidiasis increases in incidence with age, the elderly being affected most and gastrointestinal (GI) candidiasis also increases in incidence with age. Until recently, Candida glabrata was considered a relatively nonpathogenic fungal organism, however, with the increased use of immunosuppressive agents, mucosal and systemic infections caused by C. glabrata have increased significantly, especially in the human immunodeficiency virus-infected population. A major obstacle in C. glabrata infections is their innate resistance to azole antimycotic therapy, which is very effective in treating infections caused by other Candida species. Candida glabrata, contrasts with other Candida species in its nondimorphic blastoconidial morphology. Currently, however, there are few recognized virulence factors of C. glabrata and little is known about the host defense mechanisms that protect against infection. Most candidal infections are superficial and are associated with a benign course and full recovery. However, in immunocompromised hosts, systemic illness is associated with death in as many as 77%.The organism was sequenced as part of a study that compared five species of yeast. Identifying the mechanisms of eukaryotic genome evolution by comparative genomics is often complicated by the multiplicity of events that have taken place throughout the history of individual lineages, leaving only distorted and superimposed traces in the genome of each living organism. The hemiascomycete yeasts, with their compact genomes, similar lifestyle and distinct sexual and physiological properties, provide a unique opportunity to explore such mechanisms. Analysis of chromosome maps and genome redundancies reveal that the different yeast lineages have evolved through a marked interplay between several distinct molecular mechanisms, including tandem gene repeat formation, segmental duplication, a massive genome duplication and extensive gene loss. The genome of Candida glabrata is composed of 13 chromosomes totalling ca. 13.6 Mb. C. glabrata displays no known sexual cycle, despite the fact that haploid strains of the two distinct mating types are regularly isolated from patients.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
Chromosome A199
Chromosome B211
Chromosome C230
Chromosome D281
Chromosome E278
Chromosome F383
Chromosome G434
Chromosome H459
Chromosome I461
Chromosome J514
Chromosome K556
Chromosome L575
Chromosome M615
Mitochondrion11
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Main funding by: National Institutes of Health

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