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StatusReference proteome
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000001991
Taxonomy557436 - Lactobacillus reuteri (strain DSM 20016)
StrainDSM 20016
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000016825.1 from ENA/EMBL
Pan proteomei This proteome is part of the Lactobacillus reuteri (strain DSM 20016) pan proteome (fasta)

Lactobacilli are normal inhabitants of the gastrointestinal tract of man and animals where they are widely considered to exert a number of beneficial roles including immunomodulation, interference with enteric pathogens, and maintenance of a healthy intestinal microflora. The genus Lactobacillus presently comprises more than 50 recognized species of non pathogenic bacteria which in addition to their probiotic effects are useful to human as indispensable agents for the fermentation of foods and feed.

L. reuteri DSM 20016 T was isolated from the intestine of an adult human and is the type culture for the species. It encodes a unique cluster of 58 genes for the biosynthesis of reuterin and cobalamin (vitamin B12) that are not found in rat-derived strains. Although it shares a common origin with JCM 1112 (LACRJ), both being derived from F275, the two strains have been maintained separately for over 20 years and there are 2 regions unique to JCM 1112 that result in a 40 kb increase in genome size in JCM 1112, in addition to point mutations. In contrast to rat-derived L. reuteri strain 100-23, this strain is unable to colonize the mouse gastrointestinal tract. Comparing with rodent-derived strains 100-23 shows distinct genome inventories in host-restricted sub-populations of L. reuteri that reflects the niche characteristics in the gut of their particular vertebrate hosts, and thus L.reuteri has evolved a lifestyle specialized to these host animals (adapted from PMID 21379339).


Component nameGenome Accession(s)
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Main funding by: National Institutes of Health

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