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StatusReference proteome
Proteome IDiUP000001978
Taxonomy272563 - Peptoclostridium difficile (strain 630)
Last modifiedApril 27, 2018
Genome assembly and annotationi GCA_000009205.2 from ENA/EMBL
Pan proteomei This proteome is part of the Peptoclostridium difficile (strain 630) (Clostridium difficile) pan proteome (fasta)

Clostridium difficile, a Gram-positive, spore-forming anaerobic bacterium, is the leading cause of infectious diarrhea among patients in hospitals worldwide, causing C. difficile infection (CDI). An important nosocomial pathogen, it is frequently associated with antibiotic treatment and causes diseases ranging from antibiotic-associated diarrhea to life-threatening pseudomembraneous colitis. Although two important virulence factors of C. difficile have been shown to be exotoxins, toxin A (TcdA) and toxin B (TcdB), little is known about other factors involved in the adherence and colonization processes. In the past 5 years a new group of highly virulent C. difficile strains has emerged to cause outbreaks of increased disease severity in North America and Europe. Several studies have shown that patients infected with these PCR-ribotype 027 strains have more severe diarrhea, higher mortality and more recurrences.

Strain 630 (epidemic type X, PCR-ribotype 012) is a virulent and multidrug-resistant strain, and was isolated from a hospital patient with severe pseudomembraneous colitis, which had spread to several other patients on the same ward. It has several copies of a chimaeric genetic element comprising a group I intron and insertion element (an IStron). Where an IStron is inserted in an expressed gene it is probably precisely excised so that the gene remains functional.


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Component nameGenome Accession(s)
Plasmid pCD63010

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