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Overview

Proteinsi5,192
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000001952
Taxonomy364106 - Escherichia coli (strain UTI89 / UPEC)
StrainUTI89 / UPEC
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000013265.1 from ENA/EMBL
Pan proteomei This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)

Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material.

UTI89 is a uropathogenic E.coli (UPEC) belonging to phylogroup B2, and was recovered from a patient with an acute bladder infection. UPEC strains must adapt to life in several microbial communities in the human body, and have a complex life cycle in the bladder where they cause acute or recurrent urinary tract infection.

Componentsi

Component nameGenome Accession(s)
Proteins
Chromosome5049
Plasmid pUTI89143

Publications

  1. "Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach."
    Chen S.L., Hung C.-S., Xu J., Reigstad C.S., Magrini V., Sabo A., Blasiar D., Bieri T., Meyer R.R., Ozersky P., Armstrong J.R., Fulton R.S., Latreille J.P., Spieth J., Hooton T.M., Mardis E.R., Hultgren S.J., Gordon J.I.
    Proc. Natl. Acad. Sci. U.S.A. 2006:5977-5982(2006) [PubMed] [Europe PMC] [Abstract]
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