Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.


Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome%5Fredundancy">more...</a>)</p> 2,607
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="">proteome</a>. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000001939
Taxonomy367830 - Staphylococcus aureus (strain USA300)
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="">more...</a>)</p> GCA_000013465.1 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Staphylococcus aureus (strain NCTC 8325 / PS 47) pan proteome (fasta)
Buscoi <p>The Benchmarking Universal Single-Copy Ortholog (BUSCO) assessment tool is used, for eukaryotic and bacterial proteomes, to provide quantitative measures of UniProt proteome data completeness in terms of expected gene content. BUSCO scores include percentages of complete (C) single-copy (S) genes, complete (C) duplicated (D) genes, fragmented (F) and missing (M) genes, as well as the total number of orthologous clusters (n) used in the BUSCO assessment, and the name of the taxonomic lineage dataset used.</p> C:99.3%[S:99.3%,D:0%],F:0.4%,M:0.2%,n:450 bacillales_odb10
Completenessi <p>Complete Proteome Detector (CPD) is an algorithm which employs statistical evaluation of the completeness and quality of proteomes in UniProt, by looking at the sizes of taxonomically close proteomes. Possible values are 'Standard', 'Close to Standard' and 'Outlier'.</p> Standard

Gram-positive nonmotile coccus that grows in aerobic and anaerobic conditions, in which it forms grape-like clusters. Staphylococcus aureus is one of the major causes of community- acquired and hospital-acquired infections. It produces numerous toxins including superantigens that cause unique disease entities such as toxic-shock syndrome and staphylococcal scarlet fever.

S.aureus (strain USA300) is a meticillin-resistant clone that was isolated in September 2000. It harbors one circular chromosome and three plasmids. It has been involved in epidemiologically unassociated outbreaks of skin and soft tissue infections in healthy individuals in at least 21 US states, Canada and Europe. It is also associated with unusually invasive diseases, such as severe septicaemia and necrotising fasciitis. It is more virulent than S.aureus (strain COL) and highly invasive of major organs. It is also more resistant to killing by human polymorphonuclear leucocytes and causes greater host cell lysis. USA300 and COL were found to be related by vertical descent from a common ancestor. Resistance to beta lactams and ciprofloxacin are chromosomally encoded. Resistance to tetracycline, macrolides (erythromycin), lincosamides (clindamycin), streptogramin B and mupirocin is encoded on plasmids pUSA02 and pUSA03. Plasmid pUSA03 was detected in 46% of multidrug resistant USA300 strains in the strain population studied. All unique genes in USA300 are clustered in five novel allotypes of mobile genetic elements that encode virulence or resistance determinants. The first two genetic elements are the SCCmec IV element and ACME. The third one is a novel staphylococcal pathogenicity island, SaPI5, that encodes two enterotoxins closely related to SEQ and SEK in COL. The fourth one is prophage phiSA2usa, which carries the genes coding for the Panton-Valentine leucocidin. The fifth one is prophage phiSa3usa, which encodes staphylokinase and a chemotaxis inhibiting protein. In addition, USA300 possesses two other genetic elements present in all S.aureus genomes. They carry several gene clusters that might also contribute to pathogenesis. ACME is a 30.9 kb island of foreign DNA that is absent in other S.aureus genomes. It contains a cluster of six genes encoding a complete arginine deiminase pathway. This arginine deiminase system has potentially a role in enhancing the capacity of USA300 to grow and survive in the host. All S.aureus strains carry a native arginine deiminase cluster that is different from the ACME-encoded cluster. This ACME-encoded cluster was identified in S.epidermidis (strain ATCC 12228) but not in S.epidermidis RP6A2. USA300 might be the first S.aureus strain to have acquired ACME from S.epidermidis or other coagulase negative staphylococci.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
Plasmid pUSA015
Plasmid pUSA023
Plasmid pUSA0335


  1. "Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus."
    Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G., Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F., Perdreau-Remington F.
    Lancet 367:731-739(2006) [PubMed] [Europe PMC] [Abstract]
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again