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Overview

Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome_redundancy">more...</a>)</p> 4,456
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000001884
Taxonomy591020 - Shigella flexneri serotype X (strain 2002017)
Strain2002017
Last modifiedNovember 5, 2019
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000022245.1 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Escherichia coli (strain K12) pan proteome (fasta)
BuscoC:98%[S:98%,D:0%],F:0.9%,M:1.2%,n:781
CompletenessStandard

Shigella is a Gram-negative, non-sporulating, facultative anaerobe bacterium that causes dysentery or shigellosis in man. Shigella are highly invasive in the colon and the rectum, and are able to proliferate in the host cell cytoplasm, triggering an inflammatory reaction. Shigella was recognized as the etiologic agent for bacillary dysentery in the 1890's, and adopted as a genus in the 1950's and subgrouped into four species. However, a recent genetic study argues that Shigella emerged from multiple independent origins of E.coli 35,000-270,000 years ago and may not constitute a genus. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material. A new Chinese serotype of S. flexneri appeared in 2001 and replaced serotype 2a in 2003 as the most prevalent serotype in Henan Province. The new serotype also became the dominant serotype in 7 of the 10 other provinces under surveillance in China by 2007. It is a new variant of serotype X, and this clinical isolate 2002017 is an example. The genetic basis of serotype conversion by the acquisition of an SfX bacteriophage was identified in this study. By comparing various data a novel mechanism of epidemic persistence of S. flexneri over long periods through serotype switching to escape infection-induced immunity has been identified (adapted from PMID 19955273).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
Chromosome4170
Plasmid pSFxv_1257
Plasmid pSFxv_211
Plasmid pSFxv_38
Plasmid pSFxv_44
Plasmid pSFxv_56

Publications

  1. "Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri."
    Ye C., Lan R., Xia S., Zhang J., Sun Q., Zhang S., Jing H., Wang L., Li Z., Zhou Z., Zhao A., Cui Z., Cao J., Jin D., Huang L., Wang Y., Luo X., Bai X.
    Xu J.
    J. Clin. Microbiol. 48:419-426(2010) [PubMed] [Europe PMC] [Abstract]
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