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Overview

StatusReference proteome
Proteinsi1,290
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000001807
Taxonomy224326 - Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
StrainATCC 35210 / B31 / CIP 102532 / DSM 4680
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000008685.2 from ENA/EMBL
Pan proteomei This proteome is part of the Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680) pan proteome (fasta)

Borreliae, the causative agent of Lyme disease, are obligatorily bound to their host organisms for survival. It is a Spirochetes, a spiral-shaped bacterium. Highly specialized, motile, with two membranes, it lives primarily as an extracellular pathogen. During their life cycle they switch from the invertebrate host tick (Ixodes spec.) to various vertebrate hosts via a tick bite. It seems that Borellia have three indispensable components; a chromosome, a circular plasmid of approximately 26 kb and a linear plasmid of approximately 54 kb, each species can also contain many other plasmids. The range of vertebrates and invertebrates used as hosts is thought to be mediated by factors encoded mainly on a large number of different plasmids found in Borreliae genomes. These plasmids are characterized by their wealth of paralogous genes. It is thought that Borreliae plasmids are not stable and are frequently rearranged leading to differing plasmid content within a species. The chromosome is also involved in fission/fusion events, and the right end of the chromosome of B. burgdorferi strains is variable due to its ability to catch plasmids. During passage plasmids can be lost due to the lack of selection pressure, which can be accompanied by the inability of Borreliae to prosper in the host. It was first isolated in the early 1980s from the midgut of Ixodes ticks.

Componentsi

Component nameGenome Accession(s)
Proteins
Chromosome778
Plasmid lp5454
Plasmid cp2624
Plasmid cp98
Plasmid lp1714
Plasmid lp259
Plasmid lp28-116
Plasmid lp28-229
Plasmid lp28-319
Plasmid lp28-419
Plasmid lp3828
Plasmid lp3628
Plasmid lp56
Plasmid lp219
Plasmid lp5647
Plasmid cp32-117
Plasmid cp32-326
Plasmid cp32-433
Plasmid cp32-631
Plasmid cp32-733
Plasmid cp32-835
Plasmid cp32-927
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Main funding by: National Institutes of Health

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