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Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome%5Fredundancy">more...</a>)</p> 3,891
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="">proteome</a>. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000001472
Taxonomy410289 - Mycobacterium bovis (strain BCG / Pasteur 1173P2)
StrainBCG / Pasteur 1173P2
Last modifiedNovember 4, 2020
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="">more...</a>)</p> GCA_000009445.1 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) pan proteome (fasta)
Buscoi <p>The Benchmarking Universal Single-Copy Ortholog (BUSCO) assessment tool is used, for eukaryotic and bacterial proteomes, to provide quantitative measures of UniProt proteome data completeness in terms of expected gene content. BUSCO scores include percentages of complete (C) single-copy (S) genes, complete (C) duplicated (D) genes, fragmented (F) and missing (F) genes, as well as the total number of orthologous clusters (n) used in the BUSCO assessment.</p> C:99.2%[S:95.8%,D:3.4%],F:0.1%,M:0.7%,n:743 corynebacteriales_odb10

Mycobacterium bovis is a major cause of tuberculosis in a range of animal species and man. It was also the progenitor of the M.bovis bacillus Calmette-Guerin (BCG) strain used as a vaccine against tuberculosis. BCG was derived by serial passages on slices of potato imbibed with glycerol for 13 years. Once the strain was proven to no longer be virulent it was disseminated and different laboratories continued this passaging. This particular strain, M.bovis BCG 1173P2, has been passaged 1,173 times at the Pasteur Institute Paris, France. Different centers have different stocks of BCG, which have continued to change with time, accumulating insertion, deletion and single nucleotide polymorphisms. M.bovis BCG 1173P2 has two independent tandem duplications, DU1 and DU2; DU1 is found only in this Pasteur strain whereas different forms of DU2 are found in different BCG strains. A genealogy of BCG strains is presented in the paper as well as transcriptomic analysis of several different early and late BCG strains. It is suggested that the strains currently used for vaccine production are not optimal and that an earlier derived strain, such as those still used in Japan, might make a better vaccine, a suggestion that the authors recommend should be tested in clinical trials.

Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
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