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Overview

Proteinsi1,915
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000001452
Taxonomy373153 - Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)
StrainD39 / NCTC 7466
Last modifiedJune 23, 2018
Genome assembly and annotationi GCA_000014365.2 from ENA/EMBL
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Streptococcus pneumoniae (strain ATCC BAA-255 / R6) pan proteome (fasta)

Streptococci are non-motile, Gram-positive cocci with widely varying pathogenic potential that occur in pairs or chains. Streptococcus pneumoniae is the most common bacterial cause of acute respiratory infection and otitis media, and is estimated to result in over 1 millions deaths in children, the elderly, debilitated and immunosuppressed people every year. Since 1990 the number of penicillin-resistant strains has increased and many strains are now resistant to commonly prescribed antibiotics such as penicillin, macrolides and fluoroquinones. D39 is a serotype 2 strain, a derivative of which was used in experiments by Avery and coworkers to demonstrate that DNA is the genetic material. Although isolated in 1916, D39 remains extremely virulent in murine infection models and is perhaps the strain used most frequently in current studies of pneumococcal pathogenesis. Two different isolates of D39, separated at least 21 years ago, were sequenced and compared to each other and to an avirulent D39 derivative R6.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Proteins
Chromosome1910
Plasmid pDP15

Publications

  1. "Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6."
    Lanie J.A., Ng W.-L., Kazmierczak K.M., Andrzejewski T.M., Davidsen T.M., Wayne K.J., Tettelin H., Glass J.I., Winkler M.E.
    J. Bacteriol. 2007:38-51(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of cryptic plasmids pDP1 and pSMB1 of Streptococcus pneumoniae."
    Oggioni M.R., Iannelli F., Pozzi G.
    Plasmid 1999:70-72(1999) [PubMed] [Europe PMC] [Abstract]
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