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Overview

StatusReference proteome
Proteinsi1,528
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000001174
Taxonomy177416 - Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4)
StrainSCHU S4 / Schu 4
Last modifiedJune 23, 2018
Genome assembly and annotationi GCA_000008985.1 from ENA/EMBL
Pan proteomei This proteome is part of the Francisella endosymbiont of Amblyomma maculatum pan proteome (fasta)

Francisella tularensis is a rod-shaped Gram-negative bacterium and is the causative agent of tularemia. Tularemia can affect both humans and animals. The subspecies tularensis (Type A) and holarctica (Type B) are the ones most commonly associated with the human disease. Its natural hosts are rabbits, hares, beavers and other rodents, as well as flies and mosquitos. The disease can be transmitted by different ways: through scratches or bites from animals, through consumption of contaminated meat or water or through inhalation of bacteria. The symptoms developed by infected people directly reflect the mode of transmission: pneumonia-like illness for the airborne transmission; throat infection, stomach pain, diarrhea and vomiting for the gastrointestinal transmission; apparition of a sore at the entry point of the bacteria and swelling of the draining lymph nodes for transmission via skin wounds. Tularemia can be treated with antibiotics, but without therapy the mortality rate of respiratory tularemia can be as high as 5-30%. F.tularensis is very infectious and ten cells are sufficient to cause infection in humans. The bacterium can survive for weeks at low temperatures in water, soil or animal carcasses. During World War II, the use of F.tularensis as a biological weapon was studied by Japan, Soviet Union and USA.

Strain Schu S4 was isolated from a human source in 1941 in the USA.

Componentsi

Component nameGenome Accession(s)
Proteins
Chromosome1528
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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