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Proteome IDiUP000001039
Taxonomy471876 - Streptococcus pyogenes serotype M49 (strain NZ131)
Last modifiedMay 30, 2018
Genome assembly and annotationi GCA_000018125.1 from ENA/EMBL
Pan proteomei This proteome is part of the Streptococcus pyogenes serotype M1 pan proteome (fasta)

The group A streptococci (GAS, Streptococcus pyogenes) are Gram-positive, nonmotile, nonsporeforming coccus that occur in chains or in pairs of cells. Individual cells are round-to-ovoid cocci, 0.6-1.0 micrometer in diameter. They are catalase-negative aerotolerant anaerobe (facultative anaerobe) which require enriched medium containing blood in order to grow. Their capsule is composed of hyaluronic acid. GAS are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. The M protein is a highly polymorphic cell-surface molecule that is antiphagocytic and forms the basis of a scheme commonly used to classify GAS strains.

Strain NZ131 serotype M49 was isolated from a case of acute post-streptococcal glomerulonephritis in New Zealand. It is unusually competent for electrotransformation and has been used extensively as a model organism for both basic genetic and pathogenesis investigations. It is also able to cause skin infections, and a Nudix gene cluster unique to serotypes M49 and M82 has been found in its genome. It also encodes 3 prophages and insertion sequences which add to its genetic diversity (adapted from PubMed 18820018).


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  1. "Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes."
    McShan W.M., Ferretti J.J., Karasawa T., Suvorov A.N., Lin S., Qin B., Jia H., Kenton S., Najar F., Wu H., Scott J., Roe B.A., Savic D.J.
    J. Bacteriol. 2008:7773-7785(2008) [PubMed] [Europe PMC] [Abstract]

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