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StatusReference proteome
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="">proteome</a>. It consists of the characters ‘UP’ followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000000803
Taxonomy7227 - Drosophila melanogaster
Last modifiedOctober 14, 2018
Genome assembly and annotationi GCA_000001215.4 from ENA/EMBL

Drosophila melanogaster is a fruit fly and the most studied species from the family Drosophilidae. It has been used as a model organism for genetic and developmental studies since the first experiments on sex-linkage and genetic recombination carried out by Thomas Hunt Morgan in the 1900s. Its importance for human health was recognized by the award of the Nobel Prize in medicine/physiology to Ed Lewis, Christiane Nusslein-Volhard and Eric Wieschaus in 1995 for their research on the genetic control of embryonic development. Moreover, recent genetic analyses have shown that around 75% of human disease genes have homologs in Drosophila melanogaster

The Drosophila melanogaster complete genome sequence was published in 2000. It contains 180 Mb (one third of which is centric heterochromatin) and approximately 14,000 protein-coding genes.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Chromosome 2L3873
Chromosome 2R4540
Chromosome 3L4382
Chromosome 3R5270
Chromosome 4200
Chromosome X3633
Chromosome Y24
Unplaced scaffolds3


  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    Venter J.C.
    Science 2000:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 2002:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
  3. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 2007:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 2005:166-175(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 2002:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
  6. Wan K., Celniker S.
    Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases
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Main funding by: National Institutes of Health

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