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Overview

Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome%5Fredundancy">more...</a>)</p> 2,829
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a>. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000000656
Taxonomy355277 - Leptospira borgpetersenii serovar Hardjo-bovis (strain JB197)
StrainJB197
Last modifiedMay 4, 2020
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000013965.1 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) pan proteome (fasta)
BuscoC:99.6%[S:99.6%,D:0%],F:0%,M:0.4%,n:239
CompletenessStandard

Leptospirosis is one of the most common zoonotic diseases in the world, resulting in high morbidity and mortality in humans and affecting global livestock production. Most infections are caused by either Leptospira borgpetersenii or Leptospira interrogans, bacteria that vary in their distribution in nature and rely on different modes of transmission. L.borgpetersenii uses a host-to-host mode of transmission, whereas L.interrogans is usually acquired from contaminated surface water. Two different strains of L. borgpetersenii serovar Hardjo have been sequenced that have distinct phenotypes and virulence. Strain JB197 was isolated from a beef steer at slaughter in the U.S.A., whereas strain L550 was isolated from a human in Australia who had contracted leptospirosis from infected cattle. These two strains have nearly identical genetic content, with subtle frameshift and point mutations being a common form of genetic variation. Starkly limited regions of synteny are shared between the large chromosomes of L.borgpetersenii and L.interrogans, probably the result of frequent recombination events between insertion sequences. The L.borgpetersenii genome is approximately 700 kb smaller and has a lower coding density than L.interrogans, indicating it is decaying through a process of insertion sequence-mediated genome reduction. Loss of gene function is not random but is centered on impairment of environmental sensing and metabolite transport and utilization. These features distinguish L.borgpetersenii from L.interrogans, a species with minimal genetic decay and that survives extended passage in aquatic environments before encountering a mammalian host. It is thought that L.borgpetersenii is evolving toward dependence on a strict host-to-host transmission cycle (modified from PubMed 16973745).

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
Chromosome 12597
Chromosome 2235
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Main funding by: National Institutes of Health

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