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Overview

StatusReference proteome
Proteinsi <p>Number of protein entries associated with this proteome: UniProtKB entries for regular proteomes or UniParc entries for redundant proteomes (<a href="/help/proteome%5Fredundancy">more...</a>)</p> 4,316
Gene counti <p>This is the total number of unique genes found in the proteome set, algorithmically computed. For each gene, a single representative protein sequence is chosen from the proteome. Where possible, reviewed (Swiss-Prot) protein sequences are chosen as the representatives.</p> - Download one protein sequence per gene (FASTA)
Proteome IDi <p>The proteome identifier (UPID) is the unique identifier assigned to the set of proteins that constitute the <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a>. It consists of the characters 'UP' followed by 9 digits, is stable across releases and can therefore be used to cite a UniProt proteome.<p><a href='/help/proteome_id' target='_top'>More...</a></p>UP000000580
Taxonomy262316 - Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
StrainATCC BAA-968 / K-10
Last modifiedJune 29, 2020
Genome assembly and annotationi <p>Identifier for the genome assembly (<a href="https://www.ensembl.org/Help/Faq?id=216">more...</a>)</p> GCA_000007865.1 from ENA/EMBL full
Pan proteomei <p>A pan proteome is the full set of proteins thought to be expressed by a group of highly related organisms (e.g. multiple strains of the same bacterial species).<p><a href='/help/pan_proteomes' target='_top'>More...</a></p> This proteome is part of the Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10) (Mycobacterium paratuberculosis) pan proteome (fasta)
BuscoC:98.1%[S:98.1%,D:0%],F:0.3%,M:1.6%,n:743
CompletenessStandard

Mycobacterium paratuberculosis strain k10 is the causative agent of Johne's disease in cattle and other ruminants. Strain k10 is a bovine clinical isolate that was isolated from a dairy herd in Wisconsin in the mid-1970s. Johne's disease symptoms include diarrhea, weight loss and decreased milk production. According to a recent study, 21% of the United States dairy herds are infected. Infected animals shed the bacterium in feces and milk, enabling dissemination to other calves, the environment and in retail milk. The genome Mycobacterium paratuberculosis strain k10 consists of a single circular chromosome. It contains more than 3000 genes that have homologs in Mycobacterium tuberculosis. Thirty-nine genes encode predicted proteins that are unique to Mycobacterium paratuberculosis. Roughly 1.5% of the genome is made up of repetitive DNA like insertion sequences, multigene families and duplicated housekeeping genes. The genome contains the complete set of enzymes for several metabolic pathways including glycolysis, the pentose phosphate pathway, the tricarboxylic acid cycle and the glyoxylate cycle. Mycobacterium paratuberculosis is unable to produce the siderophore mycobactin.

Mycobacteria have an unusual outer membrane approximately 8nm thick, despite being considered Gram-positive. The outer membrane and the mycolic acid-arabinoglactan-peptidoglycan polymer form the cell wall, which constitutes an efficient permeability barrier in conjunction with the cell inner membrane.

Componentsi <p>Genomic components encoding the proteome</p>

Component nameGenome Accession(s)
Component representationProteins
Chromosome4316

Publications

  1. "The complete genome sequence of Mycobacterium avium subspecies paratuberculosis."
    Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V.
    Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed] [Europe PMC] [Abstract]
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