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Overview

StatusReference proteome
Proteins8,038
Proteome IDiUP000000542
Taxonomy5664 - Leishmania major
StrainMHOM/IL/81/Friedlin
Last modifiedFebruary 26, 2018
Genome assembly and annotationi GCA_000002725.2 from ENA/EMBL

Leishmania is a genus of trypanosomatid parasites that are intracellular pathogens of the immune system and are the causative agents of the disease Leishmaniasis, which is an infectious disease that is transmitted by the bite of certain species of sand fly.

Over 20 Leishmania species can infect humans and cause a spectrum of diseases. The symptoms range from disfiguring cutaneous and mucocutaneous lesions to visceral disease affecting the hematopoietic organs. Leishmaniasis affects the populations of 88 tropical and subtropical countries worldwide, and there is currently no vaccine and few effective drugs for it.

Leishmania major is an Old World pathogen and the cause of cutaneous leishmaniasis mainly in North Africa, the Middle East, west India and Sudan.

The reference proteome of Leishmania major is derived from the genome sequence published in 2005. The size of the haploid genome is 33 Mb, containing 8,272 predicted protein-coding genes that are distributed throughout 36 chromosomes.

Componentsi

DownloadView all proteins
Component nameGenome Accession(s)
Proteins
Chromosome 183
Chromosome 274
Chromosome 394
Chromosome 4123
Chromosome 5123
Chromosome 6133
Chromosome 7126
Chromosome 8124
Chromosome 9161
Chromosome 10139
Chromosome 11129
Chromosome 12140
Chromosome 13158
Chromosome 14152
Chromosome 15153
Chromosome 16168
Chromosome 17152
Chromosome 18166
Chromosome 19165
Chromosome 20175
Chromosome 21221
Chromosome 22164
Chromosome 23190
Chromosome 24235
Chromosome 25252
Chromosome 26267
Chromosome 27261
Chromosome 28311
Chromosome 29295
Chromosome 30378
Chromosome 31327
Chromosome 32407
Chromosome 33337
Chromosome 34433
Chromosome 35527
Chromosome 36723

Publications

  1. "The genome of the kinetoplastid parasite, Leishmania major."
    Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G., Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A., Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M., Bianchettin G.
    , Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E., Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M., De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N., Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A., Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S., Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M., Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S., Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M., Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E., Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C., Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K., Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V., Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J., Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D., Barrell B.G., Myler P.J.
    Science 2005:436-442(2005) [PubMed] [Europe PMC] [Abstract]

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