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Overview

StatusReference proteome
Proteinsi46,932
Gene counti - Download one protein sequence per gene (FASTA)
Proteome IDiUP000000437
Taxonomy7955 - Danio rerio
StrainTuebingen
Last modifiedSeptember 20, 2018
Genome assembly and annotationi GCA_000002035.4 from Ensembl

Danio rerio commonly known as zebrafish is a tropical fish belonging to the minnow family (Cyprinidae). It is a major model for studying developmental biology; aided by the transparency of the embryo and adult body, researchers can modify the fish's genotype at the egg stage and see resulting changes as little as three days later.

Zebrafish have the ability to regenerate many of their tissues including fins, skin, heart and, in larval stages, brain. Zebrafish have been used to study cancers, including melanoma, leukemia, pancreatic cancer and hepatocellular carcinoma.

The Tubingen strain was used as the the reference strain for the genome sequencing project as it had been used extensively to identify mutations affecting embryogenesis. Sequencing revealed that 71.4% of human genes have at least one zebrafish ortholog. Currently the zebrafish genome is thought to have more than 26,000 protein-coding genes.

Componentsi

Component nameGenome Accession(s)
Proteins
Unplaced
5648
Mitochondrion13
Chromosome 11897
Chromosome 22059
Chromosome 32046
Chromosome 42507
Chromosome 52085
Chromosome 61664
Chromosome 72203
Chromosome 81736
Chromosome 91538
Chromosome 101546
Chromosome 111485
Chromosome 121353
Chromosome 131542
Chromosome 141409
Chromosome 151546
Chromosome 161631
Chromosome 171514
Chromosome 181322
Chromosome 191559
Chromosome 201640
Chromosome 211573
Chromosome 221603
Chromosome 231478
Chromosome 241155
Chromosome 251230

Publications

  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    Stemple D.L.
    Nature 2013:498-503(2013) [PubMed] [Europe PMC] [Abstract]
  2. "The complete sequence of the zebrafish (Danio rerio) mitochondrial genome and evolutionary patterns in vertebrate mitochondrial DNA."
    Broughton R.E., Milam J.E., Roe B.A.
    Genome Res. 2001:1958-1967(2001) [PubMed] [Europe PMC] [Abstract]
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