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Animal toxin annotation project

Statistics

UniProt release 2018_08 of Sep-12, 2018 contains 558,125 reviewed entries.

Total number of reviewed animal toxin entries: 5,946 .

Total number of reviewed venom protein entries: 6,389 .

Common name Scientific name Toxins Proteins
found in
venom
Species
producing
toxins
Species
secreting
venom
Snakes Serpentes 1,941 2,289 182 186
Spiders Araneae 1,414 1,489 114 115
Snails Gastropoda 1,240 1,253 107 105
Scorpions Scorpiones 786 971 69 75
Sea anemones Actiniaria 246 0 45 0
Insects Hexapoda 76 265 35 78
Lizards Anguimorpha 34 37 6 6
Fishes Teleostei 29 15 10 5
Scolopendra Scolopendridae 52 54 2 3
Mammals Mammalia 7 6 2 1
Hydra Hydroida 4 0 2 0
Toad Amphibia 76 3 16 2
Mites Acari 3 0 2 0
Starfishes Asteroidea 3 3 1 1
Worms Cerebratulus 3 0 1 0
Medusae Rhopilema 1 0 1 0
Jellyfishes Cubozoa 5 0 4 0
other metazoans - 26 4 12 2
All animals Metazoa 5,946 6,389 611 579

Venom protein targets in UniProtKB/Swiss-Prot distributed by taxonomical group. The idea for the table originates from the nomenclature proposition made by King et al. 2008 (PMID:18619481). The table proposed in this paper has been completed and links between venom proteins and targets have been added. Since this table may also help in nomenclature discussions, the descriptors (Greek letter that specifies the biological function) proposed by these authors are also indicated (see 2nd column). Note that multiple descriptors used for sodium channels are due to different modes of action on this channel. The targets are firstly ordered by types: ion channels, receptors (7TM and 1TM) and transporters, and secondly by abundance.

target: ion channel (voltage-gated and transmitter-gated) descriptor snake scorpion spider cone snail insect sea anemone all
voltage-gated sodium (Nav) channel beta, delta, iota, mu 2 362 182 96 3 91 740
potassium channel inhibitor (Includes the following 4 channels: KIR, K2P, Kv and KCa as targets) - 52 299 105 41 6 71 603
- voltage-gated potassium (Kv) channel kappa 46 194 92 23 0 67 437
- calcium-activated potassium (KCa) channel lambda 11 47 7 0 3 0 68
- inward-rectifier potassium (KIR) channel eta 0 0 0 0 1 0 1
- two-pore domain potassium (K2P) channel theta 0 0 0 0 0 0 0
nicotinic acetylcholine receptor alpha, psi 277 0 0 161 0 0 438
calcium channel inhibitor (Includes CaV and Ryr) - 55 25 133 85 7 0 322
- voltage-gated calcium (Cav) channel omega 11 3 124 79 6 0 227
- ryanodine receptor (RyR) phi 8 19 0 0 0 0 28
- P2RX receptor omicron 0 0 2 0 0 0 2
chloride channel inhibitor (Includes CLCN, CFTR and GABA(A) as targets) - 2 18 0 0 0 0 20
- voltage-gated chloride channels (CLCN) epsilon 0 18 0 0 0 0 18
- CFTR channel LAMBDA - in upper case 0 1 0 0 0 0 1
- GABA(A) receptor SIGMA - in upper case 0 0 0 0 0 0 0
glutamate receptor GAMMA - in upper case 0 0 11 19 0 0 30
HCNa nonspecific cation channel gamma 0 0 0 7 0 0 7
cyclic nucleotide-gated channel zeta 10 0 0 0 0 0 10
transient receptor potential (TRP) channel tau 0 1 4 0 0 4 20
acid-sensing ion (ASICs) channel pi 0 0 0 0 0 1 1
5-HT receptor sigma 0 0 0 1 0 0 1
target: receptor 7TM descriptor snake scorpion spider cone snail insect sea anemone all
muscarinic acetylcholine receptor - 27 0 0 0 0 0 27
adrenoceptor rho 13 12 0 1 0 0 27
bradykinin receptor - 6 2 5 0 10 0 92
dopamine receptor - 1 0 0 0 0 0 1
vasopressin/oxytocin receptor upsilon 0 0 0 4 0 0 4
endothelin receptor xi 6 0 0 0 0 0 6
vasoactive intestinal polypeptide receptor - 0 0 0 0 0 0 4
glucagon-like peptide receptor - 0 0 0 0 0 0 3
somatostatin receptor - 0 0 0 2 0 0 2
cholecystokinin receptor - 0 0 0 0 0 0 1
neurotensin receptor nu 0 0 0 3 0 0 3
target: receptor 1TM descriptor snake scorpion spider cone snail insect sea anemone all
vascular endothelial growth factor receptor - 16 0 0 0 0 0 16
epidermal growth factor receptor OMEGA - in upper case 0 0 0 0 0 4 4
target: transporter descriptor snake scorpion spider cone snail insect sea anemone all
noradrenaline transporter chi 0 0 0 9 0 0 9
glutamate transporter - 0 0 1 0 0 0 1

Snake venom proteins - 2,289 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 68.1%
at transcript level 24.1%
inferred from homology 7.8%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 2,289 1,880 unique 100%
General annotation 2,289 11,129 100%
Function 2,199 2,343 96.1%
Catalytic activity 515 517 22.5%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 2,284 25,343 99.8%
Amino acid modifications 2,078 11,624 90.8%
Cross-references 2,289 0 100%
EMBL 1,366 0 59.7%
InterPro 1,994 0 87.1%
PDB 248 0 10.8%

100% of reviewed snake venom proteins entries are annotated with at least one keyword .

100% of reviewed snake venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Snail venom proteins - 1,253 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 40.4%
at transcript level 42.7%
inferred from homology 16.8%
predicted N/A
uncertain 0.2%

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,253 495 unique 100%
General annotation 1,253 5,478 100%
Function 595 607 47.5%
Catalytic activity 4 4 0.3%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 1,238 8,224 98.8%
Amino acid modifications 1,134 4,181 90.5%
Cross-references 1,239 0 100%
EMBL 767 0 61.2%
InterPro 786 0 62.7%
PDB 83 0 6.6%
Conoserver 865 0 69%

100% of reviewed snail venom proteins entries are annotated with at least one keyword .

98.4% of reviewed snail venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Scorpion venom proteins - 971 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 60.5%
at transcript level 26%
inferred from homology 13.6%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 971 683 unique 100%
General annotation 971 3,827 100%
Function 860 895 88.6%
Catalytic activity 16 16 1.6%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 966 5,942 99.5%
Amino acid modifications 797 2,878 82.1%
Cross-references 971 0 100%
EMBL 520 0 53.6%
InterPro 714 0 73.5%
PDB 100 0 10.3%

100% of reviewed scorpion venom proteins entries are annotated with at least one keyword .

100% of reviewed scorpion venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

Spider venom proteins - 1,489 reviewed entries.

Evidence for the existence of protein Percentage of entries
at protein level 45.1%
at transcript level 48.8%
inferred from homology 6.2%
predicted N/A
uncertain N/A

Annotation categories Entries with Number of annotations Coverage
PubMed citations 1,489 447 unique 100%
General annotation 1,489 6,738 100%
Function 1,192 1,198 80.1%
Catalytic activity 217 217 14.6%
Subcellular location 0 0 N/A
Toxic dose 0 0 N/A
Sequence annotation 1,479 9,964 99.3%
Amino acid modifications 1,285 4,229 86.3%
Cross-references 1,489 0 100%
EMBL 1,046 0 70.2%
InterPro 1,170 0 78.6%
PDB 78 0 5.2%
ArachnoServer 1,140 0 76.6%

100% of reviewed spider venom proteins entries are annotated with at least one keyword .

100% of reviewed spider venom proteins entries are annotated with at least one GO (Gene Ontology ) term.

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