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Graphical

CytoplasmSarcoplasmMyofibrilSarcomereZ lineI band

Definition

Z-disks are the lateral boundaries of a single sarcomere. In electron micrographs of cross striated muscle the Z line appears as a series of dark lines. They represent a key interface between the contractile apparatus and the cytoskeleton. The Z line (from the German "Zwischen") largely consists of alpha-actinin homodimers organized in an antiparallel fashion, thereby providing a backbone for the insertions of actin-based thin filaments, as well as titin and nebulin/nebulette. Z line of neighbouring sarcomeres are aligned in parallel and connected via the intermediate filament protein desmin. They maintain the actin filaments in a tetragonal lattice.

Synonyms

Z-band
Z bodies
Z body
Z disc
Z-disc
Z disk
Z-disk
Z-line

Category

› Cellular component

Gene Ontology

More...
GOi

Z disc [ GO:0030018 ]
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