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Graphical

Cell junctionPodosomeCell projection

Definition

The podosome is a ring-like cell protrusion which mediates cell-extracellular matrix interactions. Podosomes are composed of an actin-bundle core, flanked by a ring containing adhesion proteins connected to the core via dome-like radial actin fibers. Podosomes are rich in actin filaments, matrix-degrading enzymes, focal adhesion molecules and molecules involved in vesicle trafficking. These structures protrudes into the extracellular matrix and are essential for invasion and metastasis. Classical podosomes are highly dynamic structures formed by cell types of monocytic origin, such as macrophages, dendritic cells, and osteoclasts.

Category

› Cellular component

GOi

podosome [ GO:0002102 ]
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Main funding by: National Institutes of Health

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