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Graphical

Cell projectionFilopodium

Definition

The filopodium is a thin, tubular, finger-like cell protrusion filled with straight bundled, crosslinked actin filaments having their barbed ends directed towards the cell membrane. Filopodium are observed at the advancing front of the migrating cell and are implicated in cell motility as well as in cell-substrate adhesion. Filopodia explore the environment and form nascent adhesive structures in response to external signaling cues. These long and highly dynamic protrusions, which can extend and retract, are involved in mesenchymal migration. They are observed in many cell types, such as amoebae, keratinocytes, fibroblasts and in neurite growth cones.

Synonyms

Filopodia
Microspike

Category

› Cellular component

Gene Ontology

More...
GOi

filopodium [ GO:0030175 ]
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Main funding by: National Institutes of Health

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