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Paranodal septate junctionCell junction


The paranodal septate junction (PSJ) in vertebrate species is an occluding complex which occurs between neurons and the glial cells that myelinate them, the oligodendrocytes and the Schwann cells. Each glial cell wraps around and contacts the neuron multiple times in a spiral pattern to form the paranodal loops. The paranodal loops tightly adhere to the axon through a continuous spiral of axo-glial junctions that resemble invertebrate septate junctions (SJs). The paranodal loops are a spiraled cytoplasmic channel that is contiguous with the perikaryon of the myelin forming cell and thus can serve as a conduit for transmitting axonally induced signals that could regulate glial gene transcription. These junctions also form a physical barrier that prevents diffusion of nodal sodium channels and juxtaparanodal potassium channels. Axo-glial paranodal junctions, therefore, share adhesion, diffusion barrier and putative intercellular communication functions with invertebrate SJs.


Paranodal junction


› Cellular component

Gene Ontology


paranodal junction [ GO:0033010 ]
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