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Keyword - Restriction-modification system evasion by virus (KW-1258)

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Broader

Definition

Viral anti-restriction protein that counteracts the host restriction-modification (R-M) system. R-M system is a prokaryotic host defense system that recognizes incoming unmodified viral DNA and rapidly degrades it. Methylation and phosphorothioation (S-modification) are two known modifications used by the host to to label its genomic DNA as 'self'. Many prokaryotic viruses have evolved antirestriction strategies such as expressing their own methylase, stimulating the host methylase so that it confers protection to the virus genome or shutting down host restriction endonuclease.

Category

Biological process

Gene Ontology

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GOi

restriction-modification system evasion by virus [ GO:0099018 ]

Graphical

Host-virus interactionRestriction-modification system evasion by virusBiological process
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