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Keyword - Restriction-modification system evasion by virus (KW-1258)

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Viral anti-restriction protein that counteracts the host restriction-modification (R-M) system. R-M system is a prokaryotic host defense system that recognizes incoming unmodified viral DNA and rapidly degrades it. Methylation and phosphorothioation (S-modification) are two known modifications used by the host to to label its genomic DNA as 'self'. Many prokaryotic viruses have evolved antirestriction strategies such as expressing their own methylase, stimulating the host methylase so that it confers protection to the virus genome or shutting down host restriction endonuclease.


Biological process

Gene Ontology


restriction-modification system evasion by virus [ GO:0099018 ]


Host-virus interactionRestriction-modification system evasion by virusBiological process
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