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Keyword - Hemostasis impairing toxin (KW-1199)

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Definition

Toxin which interferes with hemostasis regrouping all mechanisms implicated in the cessation of blood loss through damaged vessels. Hence, hemostasis impairing toxins not only interfere with platelet aggregation, the coagulation cascade, fibrinogen depletion, and fibrin clot degradation (fibrinolysis), but also provoke hemorrhage by damaging endothelial cells or disturbing their interaction with the basement membrane. Numerous snake venom families have the capacity to interfere with hemostasis.

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Molecular function

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ToxinMolecular functionHemostasis impairing toxin
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