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Keyword - Microtubular inwards viral transport (KW-1177)

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Viral protein that allows the active transport of complete particles and viral components along microtubules toward the intracellular replication sites during virus entry. This transport, which usually involves motor proteins like dynein or polymerization/depolymerization reactions as a driving force, is mostly used by viruses that replicate their genome near or in the nucleus. Neurotropic viruses for example, often enter neurons at the terminal axon and their viral genome must be moved retrogradely to cell bodies. Viruses such as adenovirus, Adeno-associated virus, rabies virus, canine parvovirus, vaccinia, foamy virus, human papillomavirus 16 and herpes virus utilize this type of intracellular transport.


Biological process

Gene Ontology


microtubule-dependent intracellular transport of viral material towards nucleus [ GO:0075521 ]


Host-virus interactionCytoplasmic inwards viral transportVirus entry into host cellMicrotubular inwards viral transportBiological process
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