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Keyword - Viral penetration via permeabilization of host membrane (KW-1173)

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Viral membrane-penetration protein, usually associated with the viral capsid or released through partial programmed disassembly of the capsid, that locally permeabilizes the bilayer of a host membrane to allow virion penetration into the cytoplasm. Viral membrane-penetration proteins often need to be activated, mostly through endosomal acidic pH or receptor binding to display their membrane penetrating activity. Non-enveloped viruses such as parvovirus, human reovirus, BDV, BTV, rotavirus, papillomavirus, Flock house virus permeabilize the host endosomal membrane to penetrate the host cytoplasm.


  • Viral penetration via host membrane disruption by virus
  • Viral penetration via perforation of host membrane by virus


Biological process

Gene Ontology


permeabilization of host organelle membrane involved in viral entry into host cell [ GO:0039665 ]
viral entry via permeabilization of inner membrane [ GO:0099008 ]


Viral penetration via permeabilization of host membraneVirus entry into host cellViral penetration into host cytoplasmBiological process
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