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Keyword - Fusion of virus membrane with host membrane (KW-1168)

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Viral protein involved in the merging of the virion membrane with a host membrane during viral penetration into host cell. Viral fusion proteins drive this fusion reaction by undergoing a major conformational change that is triggered by interactions with the target cell. The specific trigger depends on the virus and can be exposure to low pH in the endocytic pathway or interaction of the virion with the host receptor(s). In prokaryotic viruses, host-virus membrane fusion can occur either at the host outer membrane or plasma membrane. Bacteriophages such as cystoviridae fuse their external envelope with the host outer membrane, whereas others like tectiviridae fuse their inner envelope with the host plasma membrane.


  • Viral entry into host cell via membrane fusion


Biological process

Gene Ontology


membrane fusion involved in viral entry into host cell [ GO:0039663 ]


Fusion of virus membrane with host membraneVirus entry into host cellViral penetration into host cytoplasmBiological process
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