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Keyword - Decay of host mRNAs by virus (KW-1132)

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Viral protein involved in the degradation of host mRNAs. Viruses have evolved ways of degrading host mRNAs to inhibit cellular translation. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response. Decay of host mRNAs can be achieved by endonucleotic RNA cleavage or associated with PABPC1 nuclear relocalization.


Biological process

Gene Ontology


induction by virus of catabolism of host mRNA [ GO:0039595 ]


Host-virus interactionHost gene expression shutoff by virusHost mRNA suppression by virusDecay of host mRNAs by virusEukaryotic host gene expression shutoff by virusBiological process
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