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Keyword - Inhibition of host TYK2 by virus (KW-1112)

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Viral protein involved in the evasion of the type I and III interferon pathways by inhibiting the host TYK2 protein. Upon viral infection, the TYK2 protein is activated by IFNalpha/beta or IFN-lambda stimulation leading to a series of phosphorylation events that induce transcription of several hundred IFN-responsive genes. Several viruses have evolved mechanisms to inhibit TYK2 activity thereby preventing the subsequent activation of downstream partners STAT1 and STAT2.


Biological process

Gene Ontology


suppression by virus of host TYK2 activity [ GO:0039574 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host TYK2 by virusInhibition of host interferon signaling pathway by virusBiological process
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