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Keyword - Inhibition of eukaryotic host transcription initiation by virus (KW-1111)

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Viral protein involved in the disruption of the host transcriptional machinery. Viruses have evolved ways of interacting with the cellular preinitiation complex (PIC) to shutoff host transcription initiation. For example, the TATA binding protein and TFIIH are targeted by some viral proteins and thus cannot assemble properly to form a functional PIC.


Biological process

Gene Ontology


suppression by virus of host transcription initiation from RNA polymerase II promoter [ GO:0039602 ]


Host-virus interactionHost gene expression shutoff by virusInhibition of eukaryotic host transcription initiation by virusEukaryotic host transcription shutoff by virusEukaryotic host gene expression shutoff by virusBiological process
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