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Keyword - Inhibition of host TAP by virus (KW-1107)

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Broader

Definition

Viral protein involved in the evasion of host adaptive immune response by inhibiting the TAP complex. Transporter associated with antigen (TAP), composed of two subunits TAP1 and TAP2, is required for the translocation of peptides into the ER, where they are loaded onto MHC class I. Thereafter, the viral peptides are presented to cytotoxic T lymphocytes at the cell surface and trigger immune response. The loading of peptide on MHC by TAP is targeted by several viruses including herpesviruses and retroviruses.

Category

Biological process

Gene Ontology

More...
GOi

suppression by virus of host antigen processing and presentation [ GO:0039588 ]

Graphical

Host-virus interactionInhibition of host TAP by virusViral immunoevasionInhibition of host adaptive immune response by virusBiological process
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