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Keyword - Inhibition of host TAP by virus (KW-1107)

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Viral protein involved in the evasion of host adaptive immune response by inhibiting the TAP complex. Transporter associated with antigen (TAP), composed of two subunits TAP1 and TAP2, is required for the translocation of peptides into the ER, where they are loaded onto MHC class I. Thereafter, the viral peptides are presented to cytotoxic T lymphocytes at the cell surface and trigger immune response. The loading of peptide on MHC by TAP is targeted by several viruses including herpesviruses and retroviruses.


Biological process

Gene Ontology


suppression by virus of host antigen processing and presentation [ GO:0039588 ]


Host-virus interactionInhibition of host TAP by virusViral immunoevasionInhibition of host adaptive immune response by virusBiological process
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