Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Keyword - Inhibition of host STAT1 by virus (KW-1105)

Keywords navigation

Broader

Definition

Viral protein involved in the evasion of the type I, II and III interferon pathways by inhibiting the STAT1 protein. Upon viral infection, STAT1 is activated by IFN-gamma, IFN-alpha/beta, or IFN-lambda that bind to specific cell surface receptors. While IFN-gamma induces STAT1 homodimerization, IFN-alpha/beta and IFN-lambda stimulate heterodimerization of STAT1 and STAT2, both leading to STAT1 nuclear localization and subsequent induction of IFN-stimulated genes. Many viruses interfere with STAT1 activation, often by preventing STAT1 phosphorylation and nuclear localization.

Category

Biological process

GOi

suppression by virus of host STAT1 activity [ GO:0039563 ]

Graphical

Inhibition of host STAT1 by virusHost-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host interferon signaling pathway by virusBiological process

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health