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Keyword - Inhibition of host pre-mRNA processing by virus (KW-1103)

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Viral protein involved in the disruption of host pre-mRNA processing. Viruses have evolved ways of interacting with the cellular RNA splicing machinery and regulate splicing of cellular pre-mRNAs as a part of the mechanism for shutting down the synthesis of host proteins. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response.


Biological process

Gene Ontology


suppression by virus of host mRNA processing [ GO:0039524 ]


Host-virus interactionHost gene expression shutoff by virusHost mRNA suppression by virusEukaryotic host gene expression shutoff by virusInhibition of host pre-mRNA processing by virusBiological process
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