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Keyword - Inhibition of host PKR by virus (KW-1102)

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Viral protein involved in the evasion of the interferon pathway by inhibiting the interferon induced PKR/EIF2AK2 protein. During viral replication of RNA viruses, dsRNA is produced leading to the activation of the PKR/EIF2AK2 kinase. Once activated, PKR/EIF2AK2 autophosphorylates and catalyzes the phosphorylation of many substrates including the translation initiation factor EIF2S1, leading to the inhibition of the initiation of protein synthesis. Several viral proteins prevent PKR/EIF2AK2 activation by direct interaction while others target PKR/EIF2AK2 to degradation.


Biological process

Gene Ontology


suppression by virus of host PKR activity [ GO:0039580 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host interferon signaling pathway by virusInhibition of host PKR by virusBiological process
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