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Keyword - Inhibition of host ISG15 by virus (KW-1095)

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Broader

Definition

Viral protein involved in the evasion of host immune defense by inhibiting the ISG15 protein, an ubiquitin-like modifier playing important roles in the innate immune response. Like ubiquitin, ISG15 is conjugated to lysines on numerous target proteins through its conserved C-terminal region. Viruses escape from the antiviral activity of ISG15 by direct interaction or by cleavage of ISG15 derivatives.

Category

Biological process

Gene Ontology

More...
GOi

suppression by virus of host ISG15 activity [ GO:0039579 ]

Graphical

Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host ISG15 by virusInhibition of host interferon signaling pathway by virusBiological process
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