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Keyword - Inhibition of host ISG15 by virus (KW-1095)

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Viral protein involved in the evasion of host immune defense by inhibiting the ISG15 protein, an ubiquitin-like modifier playing important roles in the innate immune response. Like ubiquitin, ISG15 is conjugated to lysines on numerous target proteins through its conserved C-terminal region. Viruses escape from the antiviral activity of ISG15 by direct interaction or by cleavage of ISG15 derivatives.


Biological process

Gene Ontology


suppression by virus of host ISG15 activity [ GO:0039579 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host ISG15 by virusInhibition of host interferon signaling pathway by virusBiological process
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