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Keyword - Inhibition of host IRF9 by virus (KW-1094)

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Viral protein involved in the evasion of the type I and III interferon pathway by inhibiting the interferon regulatory factor-9 (IRF9) protein. Viral infection triggers the phosphorylation and activation of IRF9. The activated IRF9 migrates to the nucleus leading to the transcriptional activation of several hundred IFN-responsive genes. Some viral proteins inhibit IRF9 activation by preventing its nuclear localization upon infection or by sending it to the nucleus in an inactive state.


Biological process

Gene Ontology


suppression by virus of host IRF9 activity [ GO:0039560 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host IRF9 by virusInhibition of host interferon signaling pathway by virusBiological process
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