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Keyword - Inhibition of host IRF3 by virus (KW-1092)

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Broader

Definition

Viral protein involved in the evasion of host innate defense by inhibiting the interferon regulatory factor-3 (IRF3) protein. Viral infection triggers the phosphorylation and activation of IRF3. The activated IRF3 migrates to the nucleus, where it complexes with the transcription coactivator CREBBP/EP300, leading to the transcriptional activation of the IFN-alpha and IFN-beta genes. Several viral proteins directly bind to IRF3 and inhibit its transcriptional activity while others target it to the proteasome for degradation.

Category

Biological process

Gene Ontology

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GOi

suppression by virus of host IRF3 activity [ GO:0039548 ]

Graphical

Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host IRF3 by virusInhibition of host RLR pathway by virusBiological process
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