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Keyword - Inhibition of host IRF3 by virus (KW-1092)

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Viral protein involved in the evasion of host innate defense by inhibiting the interferon regulatory factor-3 (IRF3) protein. Viral infection triggers the phosphorylation and activation of IRF3. The activated IRF3 migrates to the nucleus, where it complexes with the transcription coactivator CREBBP/EP300, leading to the transcriptional activation of the IFN-alpha and IFN-beta genes. Several viral proteins directly bind to IRF3 and inhibit its transcriptional activity while others target it to the proteasome for degradation.


Biological process

Gene Ontology


suppression by virus of host IRF3 activity [ GO:0039548 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host IRF3 by virusInhibition of host RLR pathway by virusBiological process
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