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Keyword - Inhibition of host complement factors by virus (KW-1087)

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Broader

Definition

Viral protein involved in the evasion of host humoral response by inhibiting the complement factors. The activation of complement involves the sequential proteolyis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. Some herpesviruses, poxviruses and retroviruses mimic or interact with complement regulatory proteins to block complement activation and neutralization of virus particles.

Category

Biological process

Gene Ontology

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GOi

suppression by virus of host complement activation [ GO:0039573 ]

Graphical

Host-virus interactionViral immunoevasionInhibition of host complement factors by virusBiological process
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