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Keyword - Inhibition of host tetherin by virus (KW-1084)

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Viral protein involved in the evasion of host immune defense by inhibiting the BST2/tetherin protein. BST2/tetherin is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses, including human immunodeficiency virus type 1 (HIV-1), HIV-2, as well as other retroviruses. Several viruses manage to circumvent the antiviral activity of BST2/tetherin either by sending BST2/tetherin to degradation (HIV-1) or by lowering the presence of BST2 on cell surfaces (HIV-2).


Biological process

Gene Ontology


suppression by virus of host tetherin activity [ GO:0039587 ]


Host-virus interactionInhibition of host innate immune response by virusViral immunoevasionInhibition of host interferon signaling pathway by virusInhibition of host tetherin by virusBiological process
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