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Keyword - Inhibition of eukaryotic host translation factors by virus (KW-1075)

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Viral protein that inhibits or degrades host translation initiation factor(s). Viruses have evolved ways of interacting with the cellular translational machinery to shutoff host gene expression. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response. Some viruses are known to cleave host translation initiation factors like EIF3 or EIF4G, while others achieve translation inhibition by promoting dephosphorylation of some host translation initiation factors or their binding partners.


Biological process

Gene Ontology


suppression by virus of host translation initiation factor activity [ GO:0039611 ]


Host-virus interactionInhibition of eukaryotic host translation factors by virusHost gene expression shutoff by virusEukaryotic host translation shutoff by virusEukaryotic host gene expression shutoff by virusBiological process
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