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Keyword - Suppressor of RNA silencing (KW-0941)

Definition

Protein which suppresses host RNA-mediated gene silencing. The most common form of RNA-mediated gene silencing is RNA interference (RNAi), a sequence-specific RNA-degradation mechanism that operates as a natural antiviral system in plants and invertebrates cells. RNAi is mediated by small interfering RNAs (siRNA) of about 21- to 25-nt that target homologous RNAs for destruction. RNA silencing by endogenous micro-RNAs (miRNAs) may also play a role in the antiviral defences of mammals. miRNAs differ from siRNAs in that they generally base pair imperfectly with target RNAs and inhibit their translation by an unknown mechanism.

Synonyms

  • Suppressor of RNAi
  • Suppressor of RNA interference

Category

Molecular function

Graphical

Molecular functionSuppressor of RNA silencing
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Main funding by: National Institutes of Health

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