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Keyword - Tyrosine-protein kinase (KW-0829)

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Enzyme which catalyzes the transfer of the terminal phosphate of ATP to a specific tyrosine residue on its target protein. Many of these kinases play significant roles in development and cell division. Tyrosine-protein kinases can be divided into two subfamilies: receptor tyrosine kinases, which have an intracellular tyrosine kinase domain, a transmembrane domain and an extracellular ligand-binding domain; and non-receptor (cytoplasmic) tyrosine kinases, which are soluble, cytoplasmic kinases.


Molecular function

Gene Ontology


protein tyrosine kinase activity [ GO:0004713 ]


KinaseTransferaseMolecular functionTyrosine-protein kinase
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